Protective efficacy of mycobacterial 71 kilodalton cell wall associated protein using poly (DL-lactide-co-glycolide) microparticles as carrier vehicles
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چکیده
منابع مشابه
Poly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin.
Poly (DL-lactide-co-glycolide) polymers were investigated as carriers for the first line antitubercular drug rifampicin. Different formulations of PLG microparticles viz. porous, non porous and hardened exhibited sustained release of rifampicin up to 7 weeks in vitro. However, hardened PLG microparticles exhibited the most sustained release in vivo in different organs up to 6 weeks. In case of ...
متن کاملChitosan/poly(DL,lactide-co-glycolide) scaffolds for tissue engineering.
Chitosan/poly(DL-lactide-co-glycolide) (Ch/DL PLG) composite scaffolds were fabricated by freeze-drying lyophilization, and were evaluated and compared for use as a bone regeneration scaffold through measurements of the compression mechanical properties of the porous scaffolds. Also, In vitro cell culture of Sprague-Dawley rat's osteoblasts were used to evaluate the phenotype expression of cell...
متن کاملPoly(lactide-co-glycolide) microparticles as systems for controlled release of proteins -- preparation and characterization.
Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w...
متن کاملPoly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system.
Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of ad...
متن کاملPoly (lactide -co- glycolide) Fiber: An Overview
Co-polymers of lactide and glycolide, referred to as PLGA, have generated tremendous interest because of their excellent biocompatibility, biodegradability and mechanical strength. Various polymeric devices like microspheres, microcapsules, nanoparticles, pellets, implants, and films have been fabricated using these polymers. They can be transformed by spinning into filaments for subsequent fab...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 1997
ISSN: 0970-1915,0974-0422
DOI: 10.1007/bf02873068